Labetalol Prevents Intestinal Dysfunction Induced by Traumatic Brain Injury

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Labetalol Prevents Intestinal Dysfunction Induced by Traumatic Brain Injury

BACKGROUND Beta-adrenergic blockade has been hypothesized to have a protective effect on intestinal dysfunction and increased intestinal permeability associated with the epinephrine surge after traumatic brain injury (TBI). METHODS Wister rats were subjected to either a weight drop TBI, and intraperitoneally injected or not with labetalol, or a sham procedure (18 rats per group). After 3, 6, ...

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ژورنال

عنوان ژورنال: PLOS ONE

سال: 2015

ISSN: 1932-6203

DOI: 10.1371/journal.pone.0133215